2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113844A
    Ac-Gly-Lys-OMe acetate
    Ac-Gly-Lys-OMe acetate is a substrate for urokinase. Ac-Gly-Lys-OMe acetate can be used to measure the effects of small molecule inhibitors on urokinase activity.
    Ac-Gly-Lys-OMe acetate
  • HY-P10005
    D-Val-Gly-Arg-pNA
    		Substrate
    D-Val-Gly-Arg-pNA is a chromogenic substrate of TPA (tissue plasminogen activator). D-Val-Gly-Arg-pNA can be used to detect the amidolytic activity of TPA I and TPA II.
    D-Val-Gly-Arg-pNA
  • HY-116264
    CatB-IN-1
    CatB-IN-1 is an enzyme inhibitor with significant inhibitory activity against tumor invasion. CatB-IN-1 may reduce the invasiveness of tumor cells by regulating intracellular protein metabolism. CatB-IN-1 demonstrates effective anti-invasive ability in cell models and can significantly reduce the invasive ability of MCF-10A neoT cells. The structure-activity relationship study of CatB-IN-1 shows that its design can target multiple functions of cat hepsin B.
    CatB-IN-1
  • HY-127039
    Antipain
    		Inhibitor
    Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain restricts uterine DNA synthesis and function in mice.
    Antipain
  • HY-P3725
    H-Leu-Ser-Phe(NO2)-Nle-Ala-OMe TFA
    H-Leu-Ser-Phe(NO2)-Nle-Ala-OMe TFA is a substrate for chymosin.
    H-Leu-Ser-Phe(NO2)-Nle-Ala-OMe TFA
  • HY-149926
    Cathepsin Inhibitor 3
    Cathepsin Inhibitor 3 (Compound 53k) is a non-radioactive intermediate in compound [18F] 2k radioactive synthesis, which has selectivity for cathepsin S. Cathepsin Inhibitor 3 can undergo radioactive fluorination and can be used for fluorine-18 labeling research. Cathepsin Inhibitor 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Cathepsin Inhibitor 3
  • HY-P991137
    Exerenibart
    		Inhibitor
    Exerenibart is an immunoglobulin G4-κ monoclonal antibody targeting human transmembrane serine protease 6 (TMPRSS6). Exerenibart is promising for research of diseases associated with iron metabolism disorders, such as iron overload or iron deficiency.
    Exerenibart
  • HY-N4330
    Rivulariapeptolides 1155
    		Inhibitor
    Rivulariapeptolides 1155 is a potent serine protease inhibitor with IC50s of 41.84, 4.94, 56.54 nM for chymotrypsin, elastase, prpteinase K, respectively.
    Rivulariapeptolides 1155
  • HY-163185
    DCLK1-IN-4
    		Inhibitor
    DCLK1-IN-4 (compound D2) is a potent and selective doublecortin-like kinase 1 (DCLK1) inhibitor with an IC50 of 70 nM. DCLK1-IN-4 can be used for the research of cancer.
    DCLK1-IN-4
  • HY-134432A
    Boc-Gln-Ala-Arg-AMC hydrochloride
    Boc-Gln-Ala-Arg-AMC hydrochloride is a fluorogenic substrate for trypsin. Boc-Gln-Ala-Arg-AMC hydrochloride can also be used for measuring the proteolytic activity of TMPRSS2.
    Boc-Gln-Ala-Arg-AMC hydrochloride
  • HY-P0133
    (Arg) 9
    		Inhibitor
    (Arg)9 (Nona-L-arginine) is a cell-penetrating peptide (CPP) made up of 9 arginine residues, which is an inhibitor of serine endoprotease Furin. (Arg)9 has neuroprotective property, exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
    (Arg) 9
  • HY-161902
    MI-1904
    		Inhibitor
    MI-1904 is the inhibitor for matriptase/TMPRSS2, that exhibits antiviral activity against influenza virus H1N1 and H9N2. MI-1904 blocks the cleavage of glycoproteins on the viral surface, prevents the virus from binding to host cell receptors, and thus inhibits the entry and replication of the virus.
    MI-1904
  • HY-P4254
    H-Gly-Glu-pNA
    		Substrate
    H-Gly-Glu-pNA is a chromogenic peptide substrate that can be widely used in enzymatic analysis, including trypsin and urokinase-type plasminogen activator (uPA).
    H-Gly-Glu-pNA
  • HY-E70392
    Recombinant Trypsin
    Recombinant Trypsin is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine.
    Recombinant Trypsin
  • HY-N4332
    Rivulariapeptolides 1121
    		Inhibitor
    Rivulariapeptolides 1121 is a high potent and selective serine protease inhibitor with IC50 values of 35.52 nM, 13.24 nM and 48.05 nM for chymotrypsin, elastase and proteinase K, respectively.
    Rivulariapeptolides 1121
  • HY-152150
    Thrombin inhibitor 7
    		Inhibitor
    Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC50 values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity.
    Thrombin inhibitor 7
  • HY-117291
    XMD-17-51
    		Inhibitor
    XMD-17-51 is a pyrimido-diazepinone compound that is able to modulate protein kinases.
    XMD-17-51
  • HY-137495A
    GGACK hydrochloride
    		Inhibitor
    GGACK (H-Glu-Gly-Arg-CMK) hydrochloride is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor.
    GGACK hydrochloride
  • HY-P4460
    AAA-pNA
    AAA-pNA is a chromogenic substrate of Tripeptidyl-peptidase II. AAA-pNA can be used to test Tripeptidyl-peptidase II activity.
    AAA-pNA
  • HY-E70228
    Cathepsin H, human liver
    Cathepsin H, human liver is an aminopeptidase and an endopeptidase. Involved in the catabolism of proteins in the lysosomal system. Cathepsin H, human liver has a key role in the regulation of the biological behavior of tumor cells and the pathological processes of brain diseases.
    Cathepsin H, human liver
Cat. No. Product Name / Synonyms Application Reactivity